2. Signaling Pathways
  3. Membrane Transporter/Ion Channel
    Neuronal Signaling
  4. Calcium Channel

Calcium Channel

Ca2+ channels; Ca channels

Calcium Channel

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Calcium channel is an ion channel which displays selective permeability to calcium ions. It is sometimes synonymous as voltage-dependent calcium channel, although there are also ligand-gated calcium channels. Voltage-gated calcium (CaV) channels catalyse rapid, highly selective influx of Ca2+ into cells despite a 70-fold higher extracellular concentration of Na+. Some calcium channel blockers have the added benefit of slowing your heart rate, which can further reduce blood pressure, relieve chest pain (angina) and control an irregular heartbeat.

Calcium Channel Isoform Specific Products:

Calcium Channel Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-B0166E
    L-Ascorbic acid magnesium
    		Inhibitor
    L-Ascorbic acid (L-Ascorbate) magnesium, an electron donor, is an endogenous antioxidant. L-Ascorbic acid selectively inhibits Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen deposition promoter and elastin production inhibitor. L-Ascorbic acid exhibits anticancer effects by generating reactive oxygen species (ROS) and selectively damaging cancer cells.
    L-Ascorbic acid magnesium
  • HY-P0033A
    Argireline acetate
    		Inhibitor
    Argireline acetate (Acetyl hexapeptide-3 acetate) is a non-toxic, skin-permeable, antiwrinkle peptide. Argireline acetate significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline acetate has antiwrinkle and anti-aging activity.
    Argireline acetate
  • HY-B0317H
    Amlodipine orotate
    		Antagonist
    Amlodipine orotate, an antianginal agent and an orally active dihydropyridine calcium channel blocker, works by blocking the voltage-dependent L-type calcium channels, thereby inhibiting the initial influx of calcium. Amlodipine orotate can be used for the research of high blood pressure and cancer.
    Amlodipine orotate
  • HY-169819
    Calcium influx inducer compound 634
    		Inducer
    Calcium influx inducer compound 634 is a calcium influx inducer. Calcium influx inducer compound 634 (10 µM) enhances the release of extracellular vesicles (EVs) from mouse bone marrow-derived dendritic cells (mBMDCs). Calcium influx inducer compound 634 (10 µM) also increases the levels of CD86 and CD80 on the surface of mBMDCs, an effect that can be blocked by the calcium release-activated calcium channel inhibitor YM-58483 (HY-100831).
    Calcium influx inducer compound 634
  • HY-159201
    24-Oxo-25-hydroxyvitamin D3
    		Activator
    24-Oxo-25-hydroxyvitamin D3 is a vitamin D3 metabolite and an intermediate in the renal mitochondrial side-chain oxidation pathway. 24-Oxo-25-hydroxyvitamin D3 enhances intestinal calcium transport in rats. 24-Oxo-25-hydroxyvitamin D3 can be used in studies related to X-linked hypophosphatemic rickets.
    24-Oxo-25-hydroxyvitamin D3
  • HY-N7848R
    Linoleamide (Standard)
    		Inhibitor
    1-Phenyl-2-propanol (Standard) is the analytical standard of 1-Phenyl-2-propanol. This product is intended for research and analytical applications. 1-Phenyl-2-propanol (Benzylmethylcarbinol) is a natural product.
    Linoleamide (Standard)
  • HY-135328AS
    Norverapamil-d7 hydrochloride
    		Antagonist 98.86%
    Norverapamil-d7 (hydrochloride) is a deuterium labeled Norverapamil. Norverapamil ((±)-Norverapamil), an N-demethylated metabolite of Verapamil, is a L-type calcium channel blocker and a P-glycoprotein (P-gp) function inhibitor.
    Norverapamil-d<sub>7</sub> hydrochloride
  • HY-146173
    KCa1.1 channel activator-1
    		Inhibitor
    KCa1.1 channel activator-1 (compound 1E), a Quercetin hybrid derivative, is a selective vascular KCa1.1 channel channel stimulator. KCa1.1 channel activator-1 also displays CaV1.2 channel blocking activity. KCa1.1 channel activator-1 exhibits weak myorelaxant activity.
    KCa1.1 channel activator-1
  • HY-18600AS
    Azimilide-d8 dihydrochloride
    		Inhibitor
    Azimilide-d8 (NE-10064-d8) dihydrochloride is the deuterium labeled Azimilide dihydrochloride (HY-18600A). Azimilide dihydrochloride is a class III antiarrhythmic agent, which works by blocking potassium channels in the heart. Azimilide dihydrochloride is a dual blocker of IKs (IC50 = 2.6 μM (2mM [K⁺]ₑ)) and IKr (IC50 = 1 μM (4 mM [K⁺])). Azimilide dihydrochloride blocked HERG channel at 0.1 and 1 Hz with IC50s of 1.4 μM and 5.2 μM respectively. Azimilide dihydrochloride also inhibits L-type calcium current (ICa) (IC50 = 17.8 μM) and sodium current (INa) (IC50 = 19 μM). Azimilide dihydrochloride can be used for the study of atrial fibrillation and ventricular fibrillation.
    Azimilide-d<sub>8</sub> dihydrochloride
  • HY-W838171
    Tiaramide
    Tiaramide is an anti-inflammatory agent. Tiaramide inhibits the PGE2 release. Tiaramide inhibits the rise in intracellular free Ca2+ induced by PGE2 (HY-101952) as well as Bradykinin (HY-P0206). Tiaramide inhibites Bradykinin-induced contraction.
    Tiaramide
  • HY-14836
    Elpetrigine
    		Inhibitor
    Elpetrigine (JZP 4) is a potent calcium and sodium channel blocker. Elpetrigine has anticonvulsant, antidepressant, antimania and anxiolytic effects. Elpetrigine can be used in the research of epilepsy and bipolar disorder.
    Elpetrigine
  • HY-19228
    FK 584
    		Inhibitor
    FK 584 is a potent detrusor muscle contraction inhibitor. FK 584 possesses potent antimuscarinic activity and weak calcium channel blocking activity. FK 584 has demonstrated potent detrusor muscle inhibitory activity in various experimental models with a manageable risk of mydriasis. FK 584 can be used to study overactive bladder (OAB).
    FK 584
  • HY-181612
    COX-2/CaV2.2-IN-1
    		Inhibitor
    COX-2/CaV2.2-IN-1 is an orally active and selective dual COX-2/CaV2.2 inhibitor, exhibiting a COX-2 IC50 of 0.26 μM and a CaV2.2 IC50 of 0.29 μM. COX-2/CaV2.2-IN-1 suppresses inflammatory responses and inflammatory mediator (IL-6, TNF-α, NO) production. COX-2/CaV2.2-IN-1 produces pronounced analgesic effects in diverse models of inflammatory, neuropathic, and visceral pain. COX-2/CaV2.2-IN-1 can be used for the research of chronic pain.
    COX-2/CaV2.2-IN-1
  • HY-121452
    Migrastatin
    		Inhibitor
    Migrastatin is a typical Fascin1 inhibitor. Migrastatin is isolated from a cultured broth of Streptomyces sp. MK929-43F1. Migrastatin inhibits tumor cell migration.
    Migrastatin
  • HY-108997A
    Palonidipine hydrochloride
    		Antagonist
    Palonidipine hydrochloride is a calcium antagonist which is potential for the therapy of angina-pectoris and hypertension.
    Palonidipine hydrochloride
  • HY-112652
    ACS-67
    		Inhibitor
    ACS-67 is a hydrogen sulphide-releasing derivative of Latanoprost acid. ACS-67 has the potential for glaucoma research.
    ACS-67
  • HY-135336AS
    (S)-Verapamil-d7 (hydrochloride)
    		Inhibitor
    (S)-Verapamil-d7 (hydrochloride) is a deuterium labeled (S)-Verapamil hydrochloride. (S)-Verapamil hydrochloride (S(-)-Verapamil hydrochloride) inhibits leukotriene C4 (LTC4) and calcein transport by MRP1. (S)-Verapamil hydrochloride leads to the death of potentially resistant tumor cells.
    (S)-Verapamil-d<sub>7</sub> (hydrochloride)
  • HY-B0166S2
    L-Ascorbic acid-13C-1
    		99.90%
    L-Ascorbic acid-13C-1 is the 13C labeled L-Ascorbic acid. L-Ascorbic acid (L-Ascorbate), an electron donor, is an endogenous antioxidant agent. L-Ascorbic acid inhibits selectively Cav3.2 channels with an IC50 of 6.5 μM. L-Ascorbic acid is also a collagen
    L-Ascorbic acid-<sup>13</sup>C-1
  • HY-B0612D
    (R)-Lercanidipine hydrochloride
    		Inhibitor 98.87%
    (R)-Lercanidipine hydrochloride is the R-enantiomer of Lercanidipine. (R)-lercanidipine hydrochloride is a calcium channel blocker.
    (R)-Lercanidipine hydrochloride
  • HY-178144
    FPR2 agonist 5
    		Activator
    FPR2 agonist 5 is a selective Formyl Peptide Receptor 2 (FPR2) agonist. FPR2 agonist 5 induces Ca2+ mobilization in FPR2-HL60 transfected cells with an EC50 of 1.2 μM and causes FPR2 desensitization with an IC50 of 0.32 μM. FPR2 agonist 5 exerts neuroprotective effects by mitigating LDH release, NO production, IL-1β, IL-6, IL-33, and IL-10 levels in LPS (HY-D1056)-induced mouse primary microglial cells. FPR2 agonist 5 can be used for the study of neuroinflammatory-related diseases.
    FPR2 agonist 5
Cat. No. Product Name / Synonyms Application Reactivity
Calcium Channel Isoform Comparison

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